HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-2-propanol → 4-{5-[2-(2-Hydroxy-propylamino)-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-2-propanol | HCID 4 | — |
| Reactant | 4-{5-[2-Chloro-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile | HCID 86708105 | — |
| Product | 4-{5-[2-(2-Hydroxy-propylamino)-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile | HCID 73052709 | — |
Reaction Steps
The title compound was prepared from 4-{5-[2-chloro-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile (Int. 19 60 mg, 0.105 mmol) and 1-amino-propan-2-ol using a similar method to that employed in Example 48 (16 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199984B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-8f79b48070894fc18a0b4a333860f595 |
| Source note | uspto-grants-2015_12 |