Triethylamine → 4-Bromo-N-[6-[2-(4-cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-butyramide

Participants

Reaction Steps

The title compound was prepared from 4-{5-[2-amino-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile (Ex. 1, 400 mg, 1.0 mmol), 4-bromo-butyryl chloride (0.5 mL, 4.32 mmol) and triethylamine (0.84 mL, 6.02 mmol) instead of DIPEA using a similar method to that employed for Intermediate 17 (362 mg).

Provenance & Evidence