Hydrochloric Acid → HCID 71280501, compound

Participants

Reaction Steps

To a flask was added tert-butyl (3,3-difluoro-1-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)cyclobutyl)carbamate (165) (169 mg, 0.3 mmol) and 4N HCl in 1,4-dioxane (1 mL). The reaction was stirred for 30 minutes. The solvent was concentrated and placed under high vacuum to afford N-(5-(5-(1-amino-3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide hydrochloride (166). MS m/z 425.2 (M+1)+.

Provenance & Evidence