Methyl chloroformate → HCID 71280654, compound

Participants

Reaction Steps

To a stirring solution of N-(5-(5-(1-amino-3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide hydrochloride (166) in anhydrous pyridine (1 mL) at 0° C. was added drop-wise methyl chloroformate (19 uL, 0.26 mmol). The reaction was stirred to room temperature for 20 minutes. The crude was concentrated and purified by preparative HPLC to yield methyl (3,3-difluoro-1-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)cyclobutyl)carbamate (F174). MS m/z 483.1 (M+1)+.

Provenance & Evidence