Hydrochloric Acid → HCID 86720686, compound

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Reaction Steps

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide (5 g, 11.90 mmol) was added to 100 mL of 37% HCl and stirred at room temperature for about 3 minutes, obtaining a yellow solution. After stirring for further 3 minutes the solution was poured into a solution of NaOH (48 g) in water (500 mL). The red solution was added with 1 M HCl to pH 1. The brown solid was filtered, washed with water, and triturated with hot EtOH (50 mL). After stirring at r.t. for 1 hour the solid was filtered, washed with EtOH and dried under vacuum at 40° C. yielding 2.4 of the title compound. MS/ESI+ [MH]+:366

Provenance & Evidence