反应详情

To a solution of 6-(4-chlorophenyl)-4,5-dihydropyridazinone (11.75 g) and glacial acetic acid (100 ml) was added dropwise 3 ml of bromine and the mixture was heated at 60°-70° C. for 3 h. The resulting mixture was cooled and slowly poured into 400 ml of cold water. The resulting white solid was filtered and dried to yield 10.83 g (89%) of 6-(4-chlorophenyl)pyridazinone.

1. temperaturethe mixture was heated at 60°-70° C. for 3 h
2. temperatureThe resulting mixture was cooled
3. filtrationThe resulting white solid was filtered
4. customdried