2-Chlorophenylhydrazine hydrochloride → HCID 58204707, compound

HRID 1498086Notes

Reaction equation

HRID 1498086 reaction equation
CN([CH:4]=[N:5][C:6]([C:8]1[N:9]=[C:10]2[C:16]3[CH:17]=[C:18]([C:21]([O:23][CH3:24])=[O:22])[CH:19]=[CH:20][C:15]=3[O:14][CH2:13][CH2:12][N:11]2[CH:25]=1)=O)C.Cl.[Cl:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[NH:34][NH2:35]>>[Cl:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[N:34]1[C:6]([C:8]2[N:9]=[C:10]3[C:16]4[CH:17]=[C:18]([C:21]([O:23][CH3:24])=[O:22])[CH:19]=[CH:20][C:15]=4[O:14][CH2:13][CH2:12][N:11]3[CH:25]=2)=[N:5][CH:4]=[N:35]1

Participants

3

Reactant 2

HCID 4432872-Chlorophenylhydrazine hydrochlorideHCID 58204698HCID 58204698, compound

Product 1

HCID 58204707HCID 58204707, compoundYield 59%

Procedure

Following the procedure in Example 22, methyl 2-((dimethylamino)methylenecarbamoyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-10-carboxylate was coupled with 2-chlorophenylhydrazine hydrochloride to give methyl 2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-10-carboxylate. Yield 59%. MS(ESI+): 422.1

Sources & evidence

ORD record
ord-3817a972aef844039934fcd83fc12bb9
Source dataset
uspto-grants-2015_12
Patent number
US09198918B2

Reaction notes

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