1-[2-(oxan-2-yloxy)ethyl]-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → HCID 178434601, compound

HRID 1498320Notes

Reaction equation

HRID 1498320 reaction equation
Br[C:2]1[CH:21]=[CH:20][C:5]2[C:6]3[N:10]([CH2:11][CH2:12][O:13][C:4]=2[CH:3]=1)[CH:9]=[C:8]([C:14]1[NH:15][N:16]=[C:17]([CH3:19])[N:18]=1)[N:7]=3.O1CCCCC1[O:28][CH2:29][CH2:30][N:31]1[CH:35]=[C:34](B2OC(C)(C)C(C)(C)O2)[CH:33]=[N:32]1>>[CH3:19][C:17]1[N:18]=[C:14]([C:8]2[N:7]=[C:6]3[C:5]4[CH:20]=[CH:21][C:2]([C:34]5[CH:33]=[N:32][N:31]([CH2:30][CH2:29][OH:28])[CH:35]=5)=[CH:3][C:4]=4[O:13][CH2:12][CH2:11][N:10]3[CH:9]=2)[NH:15][N:16]=1

Participants

3

Reactant 2

HCID 593418191-[2-(oxan-2-yloxy)ethyl]-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 178434600HCID 178434600, compound

Product 1

HCID 178434601HCID 178434601, compound

Procedure

8-Bromo-2-(5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diaza-benzo[e]azulene was reacted with 1-[2-(Tetrahydro-pyran-2-yloxy)-ethyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole under microwave conditions to give 254. MS(ESI+) 378.2

Sources & evidence

ORD record
ord-151c342ef2d740efb33e409247f4d44d
Source dataset
uspto-grants-2015_12
Patent number
US09198918B2

Reaction notes

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