Water → 6-Bromo-3-iodo-N-isobutylimidazo[1,2-a]pyrazin-8-amine

HRID 1498608노트

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HRID 1498608 반응식
[Br:1][C:2]1[N:3]=[C:4](S(C)(=O)=O)[C:5]2[N:6]([C:8]([I:11])=[CH:9][N:10]=2)[CH:7]=1.[CH2:16]([NH2:20])[CH:17]([CH3:19])[CH3:18].O>CN1CCCC1=O>[Br:1][C:2]1[N:3]=[C:4]([NH:20][CH2:16][CH:17]([CH3:19])[CH3:18])[C:5]2[N:6]([C:8]([I:11])=[CH:9][N:10]=2)[CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6558IsobutylamineHCID 715340426-Bromo-3-iodo-8-(methylsulfonyl)imidazo[1,2-a]pyrazine

생성물 1

HCID 715340446-Bromo-3-iodo-N-isobutylimidazo[1,2-a]pyrazin-8-amine수율 78%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

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온도
23 °C

실험 절차

To a stirred solution of 5.08 g (12.64 mmol) 6-bromo-3-iodo-8-methanesulfonyl-imidazo[1,2-a]pyrazine which was prepared according to intermediate example 1c in 100 mL 1-methylpyrrolidin-2-one were added 3.77 mL isobutylamine. After stirring at 23° C. for 2 hours, 500 mL water were added and the mixture was extracted with ethyl acetate. The organic phase was filtered, evaporated and the residue was recrystallized from methanol/water to yield 3.87 g (78%) of the title compound.

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. filtrationThe organic phase was filtered
  3. customevaporated
  4. customthe residue was recrystallized from methanol/water

출처 및 근거

ORD 기록
ord-c1c641aa4c954ff88c7ce92a323f203d
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09199999B2

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