Water → HCID 54767326, compound

Participants

Reaction Steps

To a solution of 90 mg (203 μmol) 4-{6-bromo-8-[(4-hydroxybutyl)amino]imidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide which was prepared according to intermediate example 8a in 2.0 mL tetrahydrofuran were added 68.1 mg 2-methylbut-3-yn-2-ol, 1.0 mL tetrabutylammonium fluoride (1 molar in tetrahydrofuran) and 42.8 mg bis(triphenylphosphine)palladium (II) chloride. The mixture was subjected to microwave radiation for 2 hours at 130° C. Water was added and the mixture was extracted with dichloromethane. The organic layer was washed with brine and dried over sodium sulfate. After filtration and removal of the solvent the residue was purified by chromatography to give 2.1 mg (2%) of the title compound.

Provenance & Evidence