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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1498657Generated: October 31, 2026

3-Pyridinecarboxaldehyde → 5,7-Dimethoxy-2-(pyridin-3-yl)quinazolin-4(3H)-one

https://huagongshe.com/reaction/1498657

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-PyridinecarboxaldehydeHCID 10371—
Reactant2-Amino-4,6-dimethoxybenzamideHCID 20349016—
Reactant5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-oneHCID 136037998—
Product5,7-Dimethoxy-2-(pyridin-3-yl)quinazolin-4(3H)-oneHCID 13590786448%

Reaction Steps

5,7-Dimethoxy-2-(pyridin-3-yl)quinazolin-4(3H)-one was synthesized from 2-amino-4,6-dimethoxybenzamide and 3-pyridine carboxaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 5,7-Dimethoxy-2-(pyridin-3-yl)quinazolin-4(3H)-one (105 mg, 48%) was isolated as a white solid. Selected data: MS (m/z): 284.0; MP 257-259° C. (hydrochloride).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09199990B2
Source datasetuspto-grants-2015_12
ORD IDord-5deb7b8deaea43cd96ecb63bc03adaee
Source noteuspto-grants-2015_12