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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1498659Generated: November 2, 2026

3,5-Dimethoxybenzaldehyde → 2-(3,5-dimethoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

https://huagongshe.com/reaction/1498659

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-DimethoxybenzaldehydeHCID 81747—
Reactant2-Amino-4,6-dimethoxybenzamideHCID 20349016—
Reactant5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-oneHCID 136037998—
Product2-(3,5-dimethoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-oneHCID 13590786546%

Reaction Steps

2-(3,5-dimethoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one was synthesized from 2-amino-4,6-dimethoxybenzamide and 3,5-dimethoxybenzaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 2-(3,5-dimethoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (120 mg, 46%) was isolated as a yellow solid. Selected data: MS (m/z): 343.05; MP 270-272° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09199990B2
Source datasetuspto-grants-2015_12
ORD IDord-8dc54d7a36574a99a2bebb8f17065805
Source noteuspto-grants-2015_12