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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1498667Generated: November 1, 2026

Anthranilamide → 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)quinazolin-4(3H)-one

https://huagongshe.com/reaction/1498667

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAnthranilamideHCID 6942—
Reactant4-(Pyrimidin-2-yloxy)benzaldehydeHCID 2763562—
Reactant5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-oneHCID 136037998—
Product2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)quinazolin-4(3H)-oneHCID 13603802072%

Reaction Steps

2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)quinazolin-4(3H)-one was synthesized from anthranilamide and 4-(pyrimidin-2-yloxy)-benzaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)quinazolin-4(3H)-one (222 mg, 72%) was isolated as a light beige solid. Selected data: MS (m/z): 280.98; MP 267-268° C. (decomposed).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09199990B2
Source datasetuspto-grants-2015_12
ORD IDord-a2c5d43f62fe4be5b94330824a259493
Source noteuspto-grants-2015_12