Ethyl diazoacetate → HCID 86732043, compound

Participants

Reaction Steps

To a solution of 4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-ethyl-6-vinylpyrimidine (19-3, 860 mg, 3.75 mmol, 1.0 eq.) in toluene (20 mL) at 120° C. was added ethyl diazoacetate (0.79 mL, 7.50 mmol, 2.0 eq.) dropwise and the resulting mixture was refluxed for 4 hours. Toluene was removed by roto-evaporation and the resulting residue was purified by silica gel column chromatography (0-50% ethyl acetate in hexanes) to afford ethyl-trans-2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-ethylpyrimidin-4-yl)cyclopropanecarboxylate (19-4) as a light yellow solid which was carried forward for next step without further purification. LRMS m/z (M+H) 316 found, 316 required.

Provenance & Evidence