Hydrochloric Acid → HCID 86732061, compound

Participants

Reaction Steps

To a solution of ethyl trans-2-(2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-methylpyridin-4-yl)cyclopropanecarboxylate (25-2, 96 mg, 0.320 mmol) in tetrahydrofuran (2 mL) and methanol (2 mL) was added a solution of LiOH (38 mg, 1.60 mmol) in water (2 mL). The mixture was stirred at room temperature for 3 hours, neutralized with 2 M HCl to pH 7, and concentrated. The residue was purified by silica gel column chromatography (0-8% methanol in DCM) to give trans-2-(2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-methylpyridin-4-yl)cyclopropanecarboxylic acid (25-3) as a white solid. LRMS m/z (M+H) 273 found, 273 required.

Provenance & Evidence