Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → p-Propionylbenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 4-Propanoylbenzonitrile | HCID 10773246 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | p-Propionylbenzoic acid | HCID 20202 | 98% |
반응 단계
4-Cyanopropiophenone (4.67 g, 29.3 mmol) was refluxed with 2N NaOH (90 mL, 180 mmol) and dioxane (90 mL) at 95° C. overnight. The mixture was diluted with water (150 mL), washed with ether (75 mL), acidified to pH 2 with concentrated HCl, and extracted with ether (3×75 mL). The organic phase was washed with saturated aqueous NaCl (3×75 mL), dried, and evaporated to give yellow solids (5.12 g, 98%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09200006B2 |
| 출처 데이터셋 | uspto-grants-2015_12 |
| ORD ID | ord-397c01f750874ef9a42fbc6b2b682d11 |
| 출처 메모 | uspto-grants-2015_12 |