1,4-Dioxane hydrochloride → 2-(4-Fluorophenyl)-2-(2-(piperazin-1-yl)pyrimidin-5-yl)ethanol

Participants

Reaction Steps

To a solution of tert-butyl 4-(5-(1-(4-fluorophenyl)-2-hydroxyethyl)pyrimidin-2-yl)piperazine-1-carboxylat (450 mg, 1.08 mmol) in dioxane (5 mL) was added HCl/dioxane (5 mL). The mixture was stirred at RT overnight. LCMS showed the reaction was completed. The solution was concentrated and purified by silica gel chromatography (DCM:CH3OH=10:1) to get the title compound as a yellow solid (0.2 g, 53%). MS (ES+) C16H19FN4O requires: 302. found: 303 [M+H]+.

Provenance & Evidence