1,4-Dioxane hydrochloride → HCID 118023124, compound

HRID 1498862Notes

Reaction equation

HRID 1498862 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:12]=[N:13][C:14]([N:17]3[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)=[N:15][CH:16]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[ClH:30].O1CCOCC1>O1CCOCC1>[ClH:30].[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:12]=[N:13][C:14]([N:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[N:15][CH:16]=2)(=[O:9])=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 118022880HCID 118022880, compound

Product 1

HCID 118023124HCID 118023124, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 4-(5-(4-fluorophenylsulfonyl)pyrimidin-2-yl)piperazine-1-carboxylate (100 mg, 0.237 mmol) in dioxane was added 4 M HCl/dioxane (6 mL). The mixture was stirred at RT for 3 hrs and concentrated to afford the title compound as a yellow oil, which was used into the next step without further purification. MS (ES+) C14H15FN4O2S requires: 322. found 323 [M+H]+.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-8f6bcb162fa948f2a97fdaec8fd3eeb5
Source dataset
uspto-grants-2015_12
Patent number
US09200002B2

Reaction notes

Loading…