Lithium borohydride → HCID 118023536, compound

Participants

Reaction Steps

To a mixture of tert-butyl 4-(5-(2-(4-fluorophenyl)-1-methoxy-1-oxopropan-2-yl)pyrimidin-2-yl)piperazine-1-carboxylate (0.4 g, 0.9 mmol) in THF (10 mL) was added LiBH4 (40 mg, 1.8 mmol). After stirred at RT for 2 h, the reaction was quenched by aq. NH4Cl and extracted with EA. The combined organic layers were washed with water and brine, dried over Na2SO4, filtered and concentrated. The residue was passed a column (silica gel, PE:EA=1:1) to afford the title compound (225 mg, 60%) as a yellow solid. MS (ES+) C22H29FN4O3 requires: 416. found: 417 [M+H]+.

Provenance & Evidence