Ethyl 4-(methylamino)-3-nitrobenzoate → Ethyl 3-amino-4-(methylamino)benzoate

Participants

Reaction Steps

Ethyl 4-methylamino-3-nitrobenzoate (6.80 g, 30.3 mmol) prepared in the Step 1-1-2 was dissolved in methanol (200 ml), and palladium 5% on carbon (1.10 g) was added to the solution. The mixture was stirred under a hydrogen flow at a room temperature overnight. The mixture was filtered, and the filtrate was concentrated to give the title compound (4.85 g, 82%) as a light-brown powder.

Provenance & Evidence