Hydrogen Bromide → 2-(4-Chloro-2-methoxyphenyl)-4-methylthiazole-5-carboxylic acid

Participants

Reaction Steps

Ethyl 2-(4-chloro-2-methoxyphenyl)-4-methylthiazole-5-carboxylate (4.83 g, 15.5 mmol) prepared in the Step 7-1-3 was suspended in ethanol (30 ml), 1 mol/l of sodium hydroxide (30 ml) was added thereto, and the mixture was heated under reflux for 1.5 hours. After being allowed to cool, the mixture was neutralized with hydrobromic acid, then separated by filtration and washed with water. The washed product was subjected to through circulation drying to give the title compound (4.28 g, 97%) as a white powder.

Provenance & Evidence