Triethylamine → HCID 86679344, compound

Participants

Reaction Steps

In toluene (3 ml), [2-(2-methylphenyl)-4-methylthiazol-5-yl]methanol (80 mg, 0.37 mmol) prepared in Example 12-2 and 1-methyl-1H-benzimidazole-5-carboxylic acid (77 mg, 0.44 mmol) prepared in Example 11-1 were suspended, and triethylamine (48 mg, 0.47=1) and then diphenylphosphoryl azide (0.12 g, 0.44 mmol) were added thereto. The mixture was heated under reflux for one hour. After being allowed to cool, the mixture was purified by silica gel column chromatography (ethyl acetate:methanol=20:1) to give the title compound (0.11 g, 75%) as a light-brown powder.

Provenance & Evidence