Dimethylformamide → HCID 86679345, compound

Participants

Reaction Steps

N,N-dimethylformamide (20 ml), methyl iodide (0.7 ml) and potassium carbonate (3.12 g) were added to 2-(4-methoxy-3-methylbenzylamino)isoindole-1,3-dione (1.67 g) prepared in the Step 15-1-2, and the mixture was stirred overnight. Methyl iodide (0.35 ml) was added thereto, and the resulting mixture was stirred for another 5 hours. Thereafter, an ethyl acetate-toluene (3:1) solution was added thereto. The resulting mixture was washed with water and a saturated saline solution in order, and then dried over sodium sulfate and concentrated under a reduced pressure. To the resulting residue, diethyl ether was added, and the mixture was stirred at a room temperature. The precipitate was separated by filtration, washed with diethyl ether, and dried under a reduced pressure to give the title compound (1.15 g, 65%).

Provenance & Evidence