2,4-Dihydroxybenzaldehyde → HCID 136607406, compound

HRID 1498929Notes

Reaction equation

HRID 1498929 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]([C:14]([NH:16][NH2:17])=[O:15])[NH:12][N:13]=1.[OH:18][C:19]1[CH:26]=[C:25]([OH:27])[CH:24]=[CH:23][C:20]=1[CH:21]=O>C(O)C>[OH:18][C:19]1[CH:26]=[C:25]([OH:27])[CH:24]=[CH:23][C:20]=1[CH:21]=[N:17][NH:16][C:14]([C:11]1[NH:12][N:13]=[C:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[CH:10]=1)=[O:15]

Participants

4

Reactant 2

HCID 72132,4-DihydroxybenzaldehydeHCID 940183HCID 940183, compound

Product 1

HCID 136607406HCID 136607406, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol (30 ml), 5-(2,4-dichlorophenyl)-2H-pyrazole-3-carboxylic acid hydrazide (136 mg) prepared in the Step 21-1-1 and 2,4-dihydroxybenzaldehyde (69 mg) was heated under reflux for 29 hours. Crystal appeared as the mixture was concentrated under a reduced pressure, the resulting crystal was separated by filtration, washed with ethanol, washed with ethyl acetate, and dried to give the title compound (129 mg, 66%).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 29 hours
  3. concentrationwas concentrated under a reduced pressure
  4. customthe resulting crystal was separated by filtration
  5. washwashed with ethanol
  6. washwashed with ethyl acetate
  7. customdried

Sources & evidence

ORD record
ord-1b8fd1b819da4a0a9d749ba0c2e7599b
Source dataset
uspto-grants-2015_12
Patent number
US09200008B2

Reaction notes

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