5-(2-Chloro-phenyl)-2H-pyrazole-3-carboxylic acid methyl ester → HCID 68642091, compound

HRID 1498936Notes

Reaction equation

HRID 1498936 reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]([C:14]([O:16]CC)=O)[NH:12][CH:13]=1.ClC1C=CC=CC=1C1C=C(C(OC)=O)[NH:29][N:30]=1>>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]([C:14]([NH:29][NH2:30])=[O:16])[NH:12][CH:13]=1

Participants

3

Reactant 2

HCID 434282955-(2-Chloro-phenyl)-2H-pyrazole-3-carboxylic acid methyl esterHCID 86679349HCID 86679349, compound

Product 1

HCID 68642091HCID 68642091, compoundYield 59%

Procedure

According to the same procedure as in the Step 22-1-3 except that ethyl 4-(2,3-dimethylphenyl)-1H-pyrrole-2-carboxylate obtained in the Step 24-1-3 was used instead of methyl 5-(2-chlorophenyl)-2H-pyrazole-3-carboxylate, the title compound (25 mg, 59%) was obtained.

Workup

  1. customobtained in the Step 24-1-3

Sources & evidence

ORD record
ord-e74a0a8517e242a88b6be51fdf2b5541
Source dataset
uspto-grants-2015_12
Patent number
US09200008B2

Reaction notes

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