Toluene → HCID 86679350, compound

Participants

Reaction Steps

To toluene (200 ml), (2,4-dichlorophenyl)-hydroxyiminoacetonitrile (8.60 g, 40 mmol) prepared in the Step 27-1-1, tosyl chloride (9.50 g) and triethylamine (5.0 g) were added, and the mixture was heated under reflux for 5 hours. After being allowed to cool, the mixture was washed with water and dried over anhydrous magnesium sulfate. The resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:3) to give the title compound (11.4 g, 77%).

Provenance & Evidence