Dichloromethane → HCID 68642112, compound

Participants

Reaction Steps

To dichloromethane (2 ml), 5-[1,1-dimethoxy-2-(4-methoxybenzyloxy)ethyl]-2-(2,4-dimethylphenyl)-4-methylthiazole (35 mg) prepared in the Step 31-1-3 was added, and trifluoroacetic acid (0.3 ml) and water (0.1 ml) were added thereto. Thereafter, the mixture was stirred at a room temperature for 5 hours. To the reaction solution, a saturated sodium bicarbonate solution was added, and then the resulting mixture was subjected to extraction with chloroform. The extract was washed with a saturated saline solution, and then dried over sodium sulfate and concentrated under a reduced pressure. The residue was purified by thin-layer chromatography (hexane:ethyl acetate=3:1, toluene:ethyl acetate=3:1) to give the title compound (18 mg, 57%).

Provenance & Evidence