Hydrochloric Acid → HCID 68642093, compound

Participants

Reaction Steps

Ethyl 3-nitro-4-(3-oxothiomorpholin-4-yl)benzoate (2.00 g, 6.44 mmol) prepared in the Step 40-1-2 was dissolved in ethanol (120 ml). Purified water (12 ml), iron powder (2.62 g, 47.04 mmol) and hydrochloric acid (0.5 ml) was added to the solution, and the mixture was heated under reflux for 4 hours. The mixture was concentrated, and a saturated sodium bicarbonate solution was added thereto, and the resulting mixture was subjected to extraction with chloroform. The extract was dried over anhydrous magnesium sulfate and then concentrated. The concentrate was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:2) to give the title compound (0.90 g, 53%) as a light-yellow powder.

Provenance & Evidence