Hydrochloric Acid → HCID 68017682, compound

Participants

Reaction Steps

Ethyl 3-(4-chloro-2-methoxyphenyl)isothiazole-5-carboxylate (500 mg, 1.68 mmol) prepared in the Step 44-1-2-A was suspended in ethanol (10 ml), and 1 mol/L sodium hydroxide (10 ml) was added thereto. The mixture was heated under reflux for one hour. After being allowed to cool, the mixture was neutralized with hydrochloric acid, and then separated by filtration and washed with water. The washed product was subjected to through circulation drying to give the title compound (194 mg, 43%).

Provenance & Evidence