Acetonitrile → HCID 118260394, compound

Participants

Reaction Steps

4,5-difluoro-2-(trimethylsilyl)phenyl trifluoromethanesulfonate (25 mg, 0.074 mmol), Cesium Fluoride (62 mg, 0.411 mmol), Trimethtyl phosphite (37 mg, 0.299 mmol), Acetonitrile (1 ml): Reaction Time: 4 h; Rf: 0.4 (1:3 EtOAc:Pet Ether); Thick oil; 11.8 mg, 71%; 1H NMR (400 MHz, CDCl3, TMS) δ 7.67-7.53 (m, 2H), 7.34-7.24 (m, 1H), 3.79 (s, 3H), 3.77 (s, 3H); 13C NMR (100 MHz, CDCl3, TMS) δ 153.3 (ddd, J=3.9, 12.3, 256.6 Hz), 150.3 (ddd, J=12.3, 22.4, 252.0 Hz), 129.0 (ddd, J=3.9, 6.9, 10.8 Hz), 124.2 (dt, J=3.9, 193.4 Hz), 121.3 (dd, J=11.6, J=18.5 Hz), 118.0 (t, J=17.7 Hz), 52.9 (d, J=6.2 Hz); 31P NMR (162 MHz, CDCl3) δ 18.6 (d, JPF=7.5 Hz); HRMS-ESI (m/z) calcd (C8H9F2O3P+H)+: 223.0330. found: 223.0335.

Provenance & Evidence