Ethyl bromoacetate → HCID 90013734, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of diethyl 2-(2-hydroxyethylamino)ethylphosphonate (6 g, 26.7 mmol) and K2CO3 (3.7 g, 26.7 mmol) in dry acetonitrile (80 ml) was cooled to −10° C. and ethyl bromoacetate (6.7 g, 40 mmol) was added. The reaction mixture was stirred at −10° C. for 1 h and then at room temperature for 2 days. The solvent was then removed by evaporation. Water and CHCl3 were added, the organic layer separated, washed with brine and dried over anhydrous MgSO4. After filtration, solvent was evaporated and the residue was purified by column chromatography on silica gel (CHCl3-MeOH), the ethyl 2-((2-(diethoxyphosphoryl)ethyl)(2-hydroxyethyl)amino)acetate was obtained in 64% yield (5.32g).

Provenance & Evidence