Morpholine → Pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine, 2-chloro-4-(4-morpholinyl)-

HRID 1499018Notes

Reaction equation

HRID 1499018 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[O:10][C:9]3[N:11]=[CH:12][CH:13]=[CH:14][C:8]=3[C:6]=2[N:7]=1.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>CO>[Cl:1][C:2]1[N:3]=[C:4]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[C:5]2[O:10][C:9]3[N:11]=[CH:12][CH:13]=[CH:14][C:8]=3[C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 87207584HCID 87207584, compound

Product 1

HCID 87207622Pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine, 2-chloro-4-(4-morpholinyl)-Yield 64%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4 (64 mg, 0.27 mmol) in dry methanol (10 mL) was added morpholine (55 μL, 0.62 mmol) dropwise, and the resulting reaction was stirred for 2 h at rt. The resulting precipitate was then filtered, washed with water and then a mixture of 5:1 methanol/water, and the remaining solid was dried in vacuo to furnish 5 (50 mg, 0.17 mmol, 64%) as a white solid.

Workup

  1. customthe resulting reaction
  2. filtrationThe resulting precipitate was then filtered
  3. washwashed with water
  4. additiona mixture of 5:1 methanol/water
  5. customthe remaining solid was dried in vacuo

Sources & evidence

ORD record
ord-d33397c092aa4ec3b63a392875904442
Source dataset
uspto-grants-2015_12
Patent number
US09200007B2

Reaction notes

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