m-Chloroperbenzoic acid → HCID 74539874, compound

Participants

Reaction Steps

To a solution of 4-(dibenzo[b,d]furan-2-ylmethyl)-6,7-dimethoxyisoquinoline 10 (600 mg, 1.62 mmol) in CH2Cl2 (40 mL) was added mCPBA (336 mg, 1.95 mmol) at RT under a nitrogen atmosphere. The reaction mixture was stirred at RT overnight and then this mixture was partitioned between CH2Cl2 (200 mL) and a 1 M K2CO3 aqueous solution (50 mL). The separated organic layer was washed with brine (50 mL), dried over MgSO4, filtered and evaporated to give 4-dibenzofuran-2-ylmethyl-6,7-dimethoxy-isoquinoline 2-oxide 35 (see table 7) as yellow solid (645 mg, quant. yield).

Provenance & Evidence