Sodium borohydride → HCID 117942216, compound

HRID 1499110Notes

Reaction equation

HRID 1499110 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[C:3]=1[C:9](=[O:14])[C:10]([F:13])([F:12])[F:11].[BH4-].[Na+]>CCO>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[C:3]=1[CH:9]([OH:14])[C:10]([F:11])([F:12])[F:13]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 50998361HCID 50998361, compound

Product 1

HCID 117942216HCID 117942216, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1-(2,6-dibromophenyl)-2,2,2-trifluoroethanone (CAS#1208078-23-2) (3 g, 9 mmol) in EtOH (50 mL) was added NaBH4 (340 mg, 9 mmol) at 5° C. The reaction was warmed to RT for 1 h, then extracted with EtOAc NaHCO3, brine, and dried over Na2SO4 filtered and concentrated in vacuo to provide 1-(2,6-dibromophenyl)-2,2,2-trifluoroethanol as a light yellow oil.

Workup

  1. extractionextracted with EtOAc NaHCO3, brine
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-aab73f14230d44d19039ec412ad97afc
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

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