HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 2-Phenoxy-6-(1-piperidinyl)benzenemethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2-phenoxy-6-(1-piperidinyl)Benzonitrile | HCID 117942061 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Phenoxy-6-(1-piperidinyl)benzenemethanamine | HCID 117947781 | — |
Reaction Steps
To 2-phenoxy-6-(piperidin-1-yl)benzonitrile (250 mg, 0.9 mmol) from Step 1 in 20 mL of MeOH was added Raney Nickel (5%) and NH4OH (2 mL). The reaction was stirred under 1 atm of H2 at RT for 2 h. The solid was filtered away and the filtrate was concentrated in vacuo to provide the title compound as a viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199994B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-c9b29aec1d474c0a9c8206a3d9ed77c6 |
| Source note | uspto-grants-2015_12 |