反应详情

To a solution of (5-bromo-[1,1′-biphenyl]-2-yl)methanol (2.0 g, 8.4 mmol) in CH2Cl2 (30 mL) was added Dess-Martin Periodinane (4.3 g, 10 mmol). The reaction mixture was stirred at RT for 2 h and then the solids were filtered and the resultant filtrate was concentrated in vacuo. Purification by normal phase silica gel column (EtOAc:PE=1:50) afforded 5-bromo-[1,1′-biphenyl]-2-carbaldehyde as a colorless oil.

1. filtrationthe solids were filtered
2. concentrationthe resultant filtrate was concentrated in vacuo
3. customPurification by normal phase silica gel column (EtOAc:PE=1:50)