1,4-Dioxane hydrochloride → (S)-2-benzyl 3-ethyl 2,8-diazaspiro[4.5]decane-2,3-dicarboxylate hydrochloride

HRID 1499129Notes

Reaction equation

HRID 1499129 reaction equation
[CH2:1]1[C:5]2([CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:4][C@@H:3]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:2]1[C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17].[ClH:26].O1CCOCC1>>[ClH:26].[CH2:1]1[C:5]2([CH2:6][CH2:7][NH:8][CH2:9][CH2:10]2)[CH2:4][C@@H:3]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:2]1[C:16]([O:18][CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:17]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 1179417652-Benzyl 3-ethyl (3S)-2,8-diazaspiro[4.5]decane-2,3-dicarboxylate

Product 1

HCID 117941862(S)-2-benzyl 3-ethyl 2,8-diazaspiro[4.5]decane-2,3-dicarboxylate hydrochloride

Procedure

(S)-2-Benzyl 3-ethyl 2,8-diazaspiro[4.5]decane-2,3-dicarboxylate (2.4 g, 6.9 mmol) in HCl/dioxane (50 mL, 3.3 N) was stirred for 2 h at RT. The solvent was then removed in vacuo to provide (S)-2-benzyl 3-ethyl 2,8-diazaspiro[4.5]decane-2,3-dicarboxylate hydrochloride which was used directly without further purification.

Workup

  1. customThe solvent was then removed in vacuo

Sources & evidence

ORD record
ord-805b73172bf243ee851273bb9a4d41ac
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

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