HCID 117942361, compound → HCID 117952057, compound

HRID 1499154Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4](O[C@H](C2C=CC(Cl)=CC=2N2C=CC(C)=N2)C(F)(F)F)[N:3]=1.[Cl:40][C:41]1[CH:46]=[CH:45][C:44]([C@@H:47]([OH:52])[C:48]([F:51])([F:50])[F:49])=[C:43]([N:53]2[CH:57]=[CH:56][C:55]([C:58]([F:61])([F:60])[F:59])=[N:54]2)[CH:42]=1>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:52][C@H:47]([C:44]2[CH:45]=[CH:46][C:41]([Cl:40])=[CH:42][C:43]=2[N:53]2[CH:57]=[CH:56][C:55]([C:58]([F:59])([F:60])[F:61])=[N:54]2)[C:48]([F:50])([F:51])[F:49])[N:3]=1

Participants

Reactant 2

HCID 117942361HCID 117942361, compound

HCID 117952801HCID 117952801, compound2×

Product 1

HCID 117952057HCID 117952057, compound

Procedure

The title compound was prepared as described for (S)-8-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 10d) starting with (R)-1-(4-chloro-2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanol (Intermediate 39).

Sources & evidence

ORD record: ord-38efa75e0bf147419e5bb9f63d1be228
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199994B2

Reaction notes

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