HCID 117942361, compound → HCID 117947766, compound

HRID 1499155Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4](O[C@H](C2C=CC(Cl)=CC=2N2C=CC(C)=N2)C(F)(F)F)[N:3]=1.[C:40]([C:44]1[CH:48]=[CH:47][N:46]([C:49]2[CH:54]=[C:53]([Cl:55])[CH:52]=[CH:51][C:50]=2[C@@H:56]([OH:61])[C:57]([F:60])([F:59])[F:58])[N:45]=1)([CH3:43])([CH3:42])[CH3:41]>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:61][C@H:56]([C:50]2[CH:51]=[CH:52][C:53]([Cl:55])=[CH:54][C:49]=2[N:46]2[CH:47]=[CH:48][C:44]([C:40]([CH3:43])([CH3:41])[CH3:42])=[N:45]2)[C:57]([F:59])([F:60])[F:58])[N:3]=1

Participants

Reactant 2

HCID 117942361HCID 117942361, compound

HCID 117952581HCID 117952581, compound2×

Product 1

HCID 117947766HCID 117947766, compound

Procedure

The title compound was prepared as described for (S)-8-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 10d) starting with (R)-1-(2-(3-(tert-butyl)-1H-pyrazol-1-yl)-4-chlorophenyl)-2,2,2-trifluoroethanol (Intermediate 40).

Sources & evidence

ORD record: ord-214acbcfee714a229434b87eb417baa7
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199994B2

Reaction notes

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