HCID 117942093, compound → HCID 117952894, compound

HRID 1499157Notes

Reaction equation

HRID 1499157 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:28]=2[N:34]2[CH:38]=[CH:37][C:36]([CH3:39])=[N:35]2)[C:23]([F:26])([F:25])[F:24])[N:3]=1.Cl[C:41]1C=CC([C@@H](O)C(F)(F)F)=C(N2C=CC(C3CC3)=N2)[CH:42]=1>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:28]=2[N:34]2[CH:38]=[CH:37][C:36]([CH:39]3[CH2:42][CH2:41]3)=[N:35]2)[C:23]([F:25])([F:24])[F:26])[N:3]=1

Participants

3

Reactant 2

HCID 117942093HCID 117942093, compound2×HCID 117942361HCID 117942361, compound

Product 1

HCID 117952894HCID 117952894, compound

Procedure

The title compound was prepared as described for (S)-8-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 10d) starting with (R)-1-(4-chloro-2-(3-cyclopropyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanol (Intermediate 42).

Sources & evidence

ORD record
ord-494b5657c41c4cfda697af1d79cc78d5
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

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