HCID 117941656, compound → HCID 91663312, compound

HRID 1499158Notes

Reaction equation

HRID 1499158 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[CH:32]=[CH:31][C:30](Cl)=[CH:29][C:28]=2[N:34]2[CH:38]=[CH:37][C:36]([CH3:39])=[N:35]2)[C:23]([F:26])([F:25])[F:24])[N:3]=1.FC(F)(F)[C@H](C1C(N2C=CC(C)=N2)=[N:46]C(C)=CC=1)O>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:9][CH2:10][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:19][CH2:20]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[C:28]([N:34]3[CH:38]=[CH:37][C:36]([CH3:39])=[N:35]3)=[N:46][C:30]([CH3:29])=[CH:31][CH:32]=2)[C:23]([F:26])([F:25])[F:24])[N:3]=1

Participants

3

Reactant 2

HCID 117941656HCID 117941656, compound2×HCID 117942361HCID 117942361, compound

Product 1

HCID 91663312HCID 91663312, compound

Procedure

The title compound was prepared as described for (S)-8-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 10d) starting with (S)-2,2,2-trifluoro-1-(6-methyl-2-(3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)ethanol (Intermediate 20)

Sources & evidence

ORD record
ord-7b8032bc74c3416195e40a7ba8665b85
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

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