HCID 117942361, compound → HCID 117942131, compound

HRID 1499197Notes

Reaction equation

HRID 1499197 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:28]=2N2C=CC(C)=N2)[C:23]([F:26])([F:25])[F:24])[N:3]=1.BrC1C=CC([C@@H](O)C(F)(F)F)=[C:43]([O:53][CH2:54][CH2:55][O:56]C)C=1>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:9][CH2:10][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:19][CH2:20]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:28]=2[O:56][CH2:55][CH2:54][O:53][CH3:43])[C:23]([F:24])([F:26])[F:25])[N:3]=1

Participants

3

Reactant 2

HCID 117942361HCID 117942361, compoundHCID 117942466HCID 117942466, compound

Product 1

HCID 117942131HCID 117942131, compound

Procedure

The title compound was prepared as described for (S)-8-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 10d) starting with (R)-1-(4-bromo-2-(2-methoxyethoxy)phenyl)-2,2,2-trifluoroethanol and obtained as a white solid.

Workup

  1. customobtained as a white solid

Sources & evidence

ORD record
ord-663f92b3cf6248c39ad1963b7fc7ba14
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

Loading…