1H-Indazole → HCID 117942531, compound

HRID 1499199Notes

Reaction equation

[N:1]1([C:10]2[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=2[C@@H:17]([O:22][C:23]2[N:28]=[C:27]([NH2:29])[N:26]=[C:25]([N:30]3[CH2:42][CH2:41][C:33]4([CH2:37][NH:36][C@H:35]([C:38]([OH:40])=[O:39])[CH2:34]4)[CH2:32][CH2:31]3)[CH:24]=2)[C:18]([F:21])([F:20])[F:19])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2N=C1.[NH:43]1[C:51]2C(=CC=CC=2)C=N1>>[NH2:29][C:27]1[N:26]=[C:25]([N:30]2[CH2:31][CH2:32][C:33]3([CH2:37][NH:36][C@H:35]([C:38]([OH:40])=[O:39])[CH2:34]3)[CH2:41][CH2:42]2)[CH:24]=[C:23]([O:22][C@H:17]([C:11]2[CH:12]=[CH:13][C:14]([Cl:16])=[CH:15][C:10]=2[N:1]2[C:5]3[C:4](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:51]=[N:43]2)[C:18]([F:20])([F:19])[F:21])[N:28]=1

Participants

Reactant 2

HCID 92211H-Indazole

HCID 117947656HCID 117947656, compound

Product 1

HCID 117942531HCID 117942531, compound

Procedure

The title compound was prepared as described for (S)-8-(6-((R)-1-(2-(1H-benzo[d]imidazol-1-yl)-4-chlorophenyl)-2,2,2-trifluoroethoxy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 36b) starting with 1H-indazole and obtained as a white solid.

Workup

customobtained as a white solid

Sources & evidence

ORD record: ord-b2884bc16aae4f75b39980ba0084f3b1
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199994B2

Reaction notes

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