Benzyl piperazine-1-carboxylate → HCID 117942944, compound

HRID 1499203Notes

Reaction equation

HRID 1499203 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH:38]=[CH:37][C:36]([O:39][CH:40]([CH3:42])[CH3:41])=[CH:35][CH:34]=3)=[CH:29][C:28]=2[N:43]2[CH2:48][CH2:47]N[CH2:45][CH2:44]2)[C:23]([F:26])([F:25])[F:24])[N:3]=1.N1(C(OCC2C=CC=CC=2)=[O:56])CCNCC1>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH:34]=[CH:35][C:36]([O:39][CH:40]([CH3:42])[CH3:41])=[CH:37][CH:38]=3)=[CH:29][C:28]=2[N:43]2[CH2:44][CH2:45][O:56][CH2:47][CH2:48]2)[C:23]([F:25])([F:26])[F:24])[N:3]=1

Participants

3

Reactant 2

HCID 643495Benzyl piperazine-1-carboxylateHCID 117952495(S)-8-(2-amino-6-((R)-2,2,2-trifluoro-1-(4'-isopropoxy-3-(piperazin-1-yl)-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid

Product 1

HCID 117942944HCID 117942944, compound

Procedure

The title compound was prepared as described for (S)-8-(2-amino-6-((R)-2,2,2-trifluoro-1-(4′-isopropoxy-3-(piperazin-1-yl)-[1,1′-biphenyl]-4-yl)ethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 36e) substituting morpholine for benzyl piperazine-1-carboxylate.

Sources & evidence

ORD record
ord-03f6127eb3f24956a948b44d483974e9
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

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