HRID1499204

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID358616

1-(2-bromophenyl)-2,2,2-trifluoroethanone

C8H4BrF3O

结构：Nc1nc(O[C@H](c2ccc(Cl)cc2-c2cccc(S(N)(=O)=O)c2)C(F)(F)F)cc(N2CCC3(CC2)CN[C@H](C(=O)O)C3)n1

HCID117952268

未命名化合物

PRODUCTS

生成物

结构：Nc1nc(O[C@H](c2ccccc2-c2ccccc2)C(F)(F)F)cc(N2CCC3(CC2)CN[C@H](C(=O)O)C3)n1

HCID117953011

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as described for (S)-8-(2-amino-6-((R)-1-(5-chloro-3′-sulfamoyl-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 34u) starting with 1-(2-bromophenyl)-2,2,2-trifluoroethanone.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3273fdb6f2b1467e8bf8893b9726d0c7
来源数据集: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09199994B2
来源说明: uspto-grants-2015_12

反应 SMILES

[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[CH:32]=[CH:31][C:30](Cl)=[CH:29][C:28]=2[C:34]2[CH:39]=[CH:38][CH:37]=[C:36](S(=O)(=O)N)[CH:35]=2)[C:23]([F:26])([F:25])[F:24])[N:3]=1.BrC1C=CC=CC=1C(=O)C(F)(F)F>>[C:28]1([C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=1[C@@H:22]([O:21][C:4]1[N:3]=[C:2]([NH2:1])[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=1)[C:23]([F:24])([F:25])[F:26]