HCID 117942216, compound → HCID 117951984, compound

HRID 1499220Notes

Reaction equation

HRID 1499220 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4](O[C@H](C2C=CC(Cl)=CC=2N2C=CC(C)=N2)C(F)(F)F)[N:3]=1.[Br:40][C:41]1[CH:46]=[CH:45][CH:44]=[C:43]([Br:47])[C:42]=1[CH:48]([OH:53])[C:49]([F:52])([F:51])[F:50]>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:53][CH:48]([C:42]2[C:41]([Br:40])=[CH:46][CH:45]=[CH:44][C:43]=2[Br:47])[C:49]([F:50])([F:51])[F:52])[N:3]=1

Participants

3

Reactant 2

HCID 117942216HCID 117942216, compoundHCID 117942361HCID 117942361, compound

Product 1

HCID 117951984HCID 117951984, compound

Procedure

The title compound was prepared as described for (S)-8-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 10d) starting with 1-(2,6-dibromophenyl)-2,2,2-trifluoroethanol.

Sources & evidence

ORD record
ord-a1fe2eee81b240e3b7d7be90e968375f
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

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