HCID 117947775, compound → HCID 117942345, compound

HRID 1499229Notes

Reaction equation

HRID 1499229 reaction equation
[C:1]1([C:7]2[CH:12]=[CH:11][C:10](C3C=CC=CC=3)=[CH:9][C:8]=2[C@@H:19]([O:24][C:25]2[N:30]=[C:29]([NH2:31])[N:28]=[C:27]([N:32]3[CH2:44][CH2:43][C:35]4([CH2:39][NH:38][C@H:37]([C:40]([OH:42])=[O:41])[CH2:36]4)[CH2:34][CH2:33]3)[CH:26]=2)[C:20]([F:23])([F:22])[F:21])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.NC1N=C(N2CCC3(CN(C(OC(C)(C)C)=O)[C@H](C(OCC)=O)C3)CC2)C=C(O[C@H]([C:80]2[C:85](Br)=[CH:84][CH:83]=[CH:82][C:81]=2Br)C(F)(F)F)N=1>>[C:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:80]3[CH:85]=[CH:84][CH:83]=[CH:82][CH:81]=3)[C:8]=2[C@@H:19]([O:24][C:25]2[N:30]=[C:29]([NH2:31])[N:28]=[C:27]([N:32]3[CH2:44][CH2:43][C:35]4([CH2:39][NH:38][C@H:37]([C:40]([OH:42])=[O:41])[CH2:36]4)[CH2:34][CH2:33]3)[CH:26]=2)[C:20]([F:21])([F:23])[F:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 117947775HCID 117947775, compoundHCID 117952123HCID 117952123, compound

Product 1

HCID 117942345HCID 117942345, compound

Procedure

The title compound was prepared as described for (S)-8-(6-((R)-1-([1,1′:4′,1″-terphenyl]-2′-yl)-2,2,2-trifluoroethoxy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 51a) starting with (S)-2-tert-butyl 3-ethyl 8-(2-amino-6-((R)-1-(2,6-dibromophenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-2,3-dicarboxylate (product of Step 4, example 63ao).

Sources & evidence

ORD record
ord-2b074951fd1343ddb2a970fea5b3bd17
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

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