反应详情

To a mixture of 2-chloro-4-(methylsulfonyl)benzoic acid (5 g, 21.3 mmol) in anhydrous methanol (100 mL) was added concentrated sulfuric acid (0.5 mL). The resulting solution was stirred for 18 h at reflux. Upon cooling, the mixture was concentrated under reduced pressure, dissolved in CH2Cl2 and washed with NaHCO3 solution and brine. The organic phase was dried over sodium sulfate and concentrated to afford methyl 2-chloro-4-(methylsulfonyl)benzoate as a white solid.

1. temperatureat reflux
2. temperatureUpon cooling
3. concentrationthe mixture was concentrated under reduced pressure
4. dissolutiondissolved in CH2Cl2
5. washwashed with NaHCO3 solution and brine
6. dry with materialThe organic phase was dried over sodium sulfate
7. concentrationconcentrated