Sodium borohydride → 5-(Methylsulfonyl)[1,1'-biphenyl]-2-methanol

Participants

Reaction Steps

To a solution of CaCl2 (1.52 g, 13.78 mmol) in EtOH (50 mL) at RT was added methyl 5-(methylsulfonyl)-[1,1′-biphenyl]-2-carboxylate (2 g, 6.9 mmol) in THF (50 mL) followed by the addition of NaBH4 (1.0 g, 27.6 mmol). The reaction was stirred at RT for 24 h, then concentrated in vacuo and extracted with ethyl acetate, 5% HCl, and brine. Purification on normal phase silica gel provided (5-(methylsulfonyl)-[1,1′-biphenyl]-2-yl)methanol as a white solid.

Provenance & Evidence