4-Isopropoxybenzeneboronic acid → (S)-8-(6-((R)-1-([1,1':3',1''-terphenyl]-4'-yl)-2,2,2-trifluoroethoxy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	4-Isopropoxybenzeneboronic acid	HCID 3698726	—
Reactant	(S)-8-(2-amino-6-((R)-2,2,2-trifluoro-1-(4-isopropoxy-[1,1':3',1''-terphenyl]-4'-yl)ethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid	HCID 117952891	—
Product	(S)-8-(6-((R)-1-([1,1':3',1''-terphenyl]-4'-yl)-2,2,2-trifluoroethoxy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid	HCID 117952311	—

Reaction Steps

The title compound was prepared as described above for (S)-8-(2-amino-6-((R)-2,2,2-trifluoro-1-(4-isopropoxy-[1,1′:3′,1″-terphenyl]-4′-yl)ethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 54b) by substituting phenyl boronic acid for 4-isopropoxyphenyl boronic acid in Step 2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09199994B2
Source dataset	uspto-grants-2015_12
ORD ID	ord-d70125dbc4c24c158401245fb4fb1d92
Source note	uspto-grants-2015_12